Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models. | Available online http content 7 1 29 Review The role of T cell interleukin-17 in conducting destructive arthritis lessons from animal models Erik Lubberts Marije I Koenders and Wim B van den Berg Department of Rheumatology Rheumatology Research and Advanced Therapeutics University Medical Center Nijmegen Nijmegen The Netherlands Corresponding author E Lubberts Published 30 November 2004 Arthritis Res Ther 2005 7 29-37 DOI ar1478 2004 BioMed Central Ltd Abstract Interleukin-17 IL-17 is a T cell cytokine spontaneously produced by cultures of rheumatoid arthritis RA synovial membranes. High levels have been detected in the synovial fluid of patients with RA. The trigger for IL-17 is not fully identified however IL-23 promotes the production of IL-17 and a strong correlation between IL-15 and IL-17 levels in synovial fluid has been observed. IL-17 is a potent inducer of various cytokines such as tumor necrosis factor TNF -a IL-1 and receptor activator of NF-kB ligand RANKL . Additive or even synergistic effects with IL-1 and TNF-a in inducing cytokine expression and joint damage have been shown in vitro and in vivo. This review describes the role of IL-17 in the pathogenesis of destructive arthritis with a major focus on studies in vivo in arthritis models. From these studies in vivo it can be concluded that IL-17 becomes significant when T cells are a major element of the arthritis process. Moreover IL-17 has the capacity to induce joint destruction in an IL-1-independent manner and can bypass TNF-dependent arthritis. Anti-IL-17 cytokine therapy is of interest as an additional new anti-rheumatic strategy for RA in particular in situations in which elevated IL-17 might attenuate the response to anti-TNF anti-IL-1 therapy. Keywords autoimmune diseases cytokine inflammation interleukin-23 osteoclast receptor activator of NF-kB ligand Interleukin-17 and family members Interleukin-17 IL-17 is a 17 kDa protein that is
