Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Arthritis imaging using a near-infrared fluorescence folate-targeted probe. | Available online http content 7 2 R310 Research article Arthritis imaging using a near-infrared fluorescence folate-targeted probe Wei-Tsung Chen1 2 Umar Mahmood1 Ralph Weissleder1 and Ching-Hsuan Tung1 Center of Molecular Imaging Research Massachusetts General Hospital Harvard Medical School Charlestown Massachusetts USA 2Radiology Department Taipei Municipal Jen-Ai Hospital Taipei Taiwan Corresponding author Ching-Hsuan Tung tung@ Received 2 Sep 2004 Revisions requested 1 Nov 2004 Revisions received 11 Nov 2004 Accepted 23 Nov 2004 Published 14 Jan 2005 Arthritis Res Ther 2005 7 R310-R317 DOI ar1483 2005 Chen et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Open Access Abstract A recently developed near-infrared fluorescence-labeled folate probe NIR2-folate was tested for in vivo imaging of arthritis using a lipopolysaccharide intra-articular injection model and a KRN transgenic mice serum induction mouse model. In the lipopolysaccharide injection model the fluorescence signal intensity of NIR2-folate n 12 and of free NIR2 n 5 was compared between lipopolysaccharide-treated and control joints. The fluorescence signal intensity of the NIR2-folate probe at the inflammatory joints was found to be significantly higher than the control normal joints up to P . The NIR2-free dye injection group showed a persistent lower enhancement ratio than the NIR2-folate probe injection group. Excessive folic acid was also given to demonstrate a competitive effect with the NIR2-folate. In the KRN serum transfer model n 4 NIR2-folate was applied at different time points after serum transfer and the inflamed joints could be detected as early as 30 hours after arthritogenic .
