Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: TLR2 modulates inflammation in zymosan-induced arthritis in mice. | Available online http content 7 2 R370 Research article TLR2 modulates inflammation in zymosan-induced arthritis in mice Matthias E Frasnelli David Tarussio Veronique Chobaz-Peclat Nathalie Busso and Alexander So Open Access Laboratoire de Rhumatologie Centre Hospitalier Universitaire Vaudois Lausanne Switzerland Corresponding author Alexander So aso@ Received 15 Oct 2004 Revisions requested 23 Nov 2004 Revisions received 4 Dec 2004 Accepted 10 Dec 2004 Published 21 Jan 2005 Arthritis Res Ther 2005 7 R370-R379 DOI ar1494 2005 Frasnelli et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The interplay between the innate and acquired immune systems in chronic inflammation is not well documented. We have investigated the mechanisms of inflammation in murine zymosan-induced arthritis ZIA in the light of recent data on the roles of Toll-like receptor 2 TLR2 and Dectin-1 in the activation of monocyte macrophages by zymosan. The severity of inflammation joint histology lymphocyte proliferation and antibody production in response to zymosan were analyzed in mice deficient in TLR2 and complement C3 and the effects of Dectin-1 inhibition by laminarin were studied. In comparison with wild-type animals TLR2-deficient mice showed a significant decrease in the early day 1 and late phases day 24 of joint inflammation. C3-deficient mice showed no differences in technetium uptake or histological scoring. TLR2-deficient mice also showed a significant decrease in lymph node cell proliferation in response to zymosan and a lower IgG antibody response to zymosan at day 25 in comparison with wild-type controls indicating that TLR2 signalling has a role in the development of acquired immune .
