Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion. | Available online http content 7 2 49 Commentary Building the synovium cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion Hans P Kiener and Michael B Brenner Department of Medicine Brigham and Women s Hospital Harvard Medical School Boston Massachusetts USA Corresponding author Michael B Brenner mbrenner@ Published 12 January 2005 Arthritis Res Ther 2005 7 49-54 DOI ar1495 2005 BioMed Central Ltd Abstract Specific adhesion among like cells is a key determinant of the architecture of tissues. Homophilic like binds like adhesive interactions between cells are mediated by cadherins. These integral membrane glycoproteins have a crucial role in tissue morphogenesis during development and the maintenance of tissue integrity in adults. There is also an increasing recognition of a regulatory role for cadherins in a variety of cell functions including cell migration. The recent identification of cadherin-11 expression in fibroblast-like synoviocytes FLSs has shed light on the mechanisms of synovial tissue organization and differentiation. Moreover cadherin-11 expression in FLSs might also provide insight into pathways that determine the mesenchymal tissue response of the synovium to inflammation. Introduction The synovium is a highly organized tissue that resides between the joint cavity and the fibrous joint capsule. In healthy states the predominant cell type is of mesenchymal origin and demonstrates fibroblast-like features. These cells condense and accumulate at the tissue-joint cavity interface to form a distinct structure called the synovial lining layer. Electron microscopy revealed extensive cell-to-cell contacts within the lining layer 1 . These adhesive cell interactions are probably critical for the organization as well as the structural and functional integrity of the synovial lining layer. Yet the molecular basis for these interactions is not known. The recent identification of cadherin-11 .
