Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Interleukin-18: a therapeutic target in rheumatoid arthritis? | Arthritis Research Therapy Vol 7 No 1 Mclnnes et al. Commentary Interleukin-18 a therapeutic target in rheumatoid arthritis lain B Mclnnes Foo Y Liew and J Alastair Gracie Division of Immunology Infection and Inflammation University of Glasgow UK Corresponding author Iain B McInnes Published 17 December 2004 Arthritis Res Ther 2005 7 38-41 DOI ar1497 2004 BioMed Central Ltd Abstract Interleukin 18 IL-18 a member of the IL-1 superfamily of cytokines has been demonstrated to be an important mediator of both innate and adaptive immune responses. Several reports have implicated its role in the pathogenesis of rheumatoid arthritis RA . Although biologic therapy is firmly established in the treatment of a number of inflammatory diseases including RA partial and nonresponder patients constitute residual unmet clinical need. The aim of this article is to briefly review the biology of and experimental approaches to IL-18 neutralisation together with speculation as to the relative merits of IL-18 as an alternative to existing targets. Keywords cytokine IL-18 inflammation rheumatoid arthritis Whereas TNFa antagonists provide impressive clinical benefits in rheumatoid arthritis RA partial and nonresponder patients constitute residual unmet clinical need. Establishing the therapeutic potential of individual cytokines in rheumatoid arthritis therefore assumes increasing importance. Rational choice of an appropriate target however poses significant challenges as we move from linear models of cytokine effector function in chronic inflammation to a network concept of interacting activities contributing in synergy across distinct tissue events. In particular cytokine mediated pathology may be distinct in cartilage and bone as opposed to synovial tissue or draining lymph node. For many given cytokines establishing tissue expression and local function is now relatively straightforward. However we believe that critical decision making with respect
