Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity. | Available online http content 7 3 R458 Research article Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity Karin Lundberg1 Suzanne Nijenhuis2 Erik R Vossenaar2 Karin Palmblad1 Walter J van Venrooij2 Lars Klareskog1 AJW Zendman2 and Helena Erlandsson Harris1 Rheumatology Unit Department of Medicine Karolinska Institutet Stockholm Sweden 2Department of Biochemistry Radboud University Nijmegen Nijmegen The Netherlands Corresponding author Karin Lundberg Received 21 Oct 2004 Revisions requested 2 Dec 2004 Revisions received 16 Dec 2004 Accepted 20 Jan 2005 Published 21 Feb 2005 Arthritis Research Therapy 2005 7 R458-R467 DOI 86 ar1697 2005 Lundberg et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Autoantibodies directed against citrulline-containing proteins have an impressive specificity of nearly 100 in patients with rheumatoid arthritis and have been suggested to be involved in the disease pathogenesis. The targeted epitopes are generated by a post-translational modification catalysed by the calciumdependent enzyme peptidyl arginine deiminase PAD which converts positively charged arginine to polar but uncharged citrulline. The aim of this study was to explore the effects of citrullination on the immunogenicity of autoantigens as well as on potential arthritogenicity. Thus immune responses to citrullinated rat serum albumin Cit-RSA and to unmodified rat serum albumin RSA were examined as well as arthritis development induced by immunisation with citrullinated rat collagen type II Cit-CII or unmodified CII. In addition to correlate the presence of .
