Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The determinants of change in tibial plateau bone area in osteoarthritic knees: a cohort study. | Available online http content 7 3 R687 Research article The determinants of change in tibial plateau bone area in osteoarthritic knees a cohort study Yuanyuan Wang1 2 Anita E Wluka1 and Flavia M Cicuttini1 Department of Epidemiology and PreventiveMedicine Monash UniversityMedical School Alfred Hospital Prahran Vic 3181 Australia 2Graduate School of IntegrativeMedicine Swinburne University of Technology Hawthorn Vic 31 22 Australia Corresponding author Flavia M Cicuttini Received 8 Sep 2004 Revisions requested 19 Oct 2004 Revisions received 27 Jan 2005 Accepted 2 Mar 2005 Published 31 Mar 2005 Arthritis Research Therapy 2005 7 R687-R693 DOI 86 ar1 726 This article is online at http content 7 3 R687 2005 Wang et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Bone is integral to the pathogenesis of osteoarthritis OA . Whether the bone area of the tibial plateau changes over time in subjects with knee OA is unknown. We performed a cohort study to describe this and identify factors that might influence the change. One hundred and twenty-six subjects with knee OA underwent baseline knee radiography and magnetic resonance imaging on their symptomatic knee. They were followed up with a repeatmagnetic resonance image of the same knee approximately 2 years later. The bone area of the tibial plateau was measured at baseline and follow-up. Risk factors assessed at baseline were tested for their association with change in tibial plateau bone area over time. One hundred and seventeen subjects completed the study. The medial and lateral tibial plateau bone areas increased by and per year respectively. Being male
