Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: A monoclonal antibody against kininogen reduces inflammation in the HLA-B27 transgenic rat. | Available online http content 7 4 R769 Research article A monoclonal antibody against kininogen reduces inflammation in the HLA-B27 transgenic rat James C Keith Jr1 Irma M Sainz2 Irma Isordia-Salas2 Robin A Pixley2 Yelena Leathurby1 Leo M Albert1 and Robert W Colman2 Department of Cardiovascular and Metabolic Diseases Research Wyeth Research Cambridge Massachusetts USA 2The Sol Sherry Thrombosis Research Center Temple University School of Medicine Philadelphia Pennsylania USA Corresponding author Robert W Colman colmanr@ Received 31 Jan 2005 Accepted 3 Mar 2005 Published 4 Apr 2005 Arthritis Research Therapy 2005 7 R769-R776 DOI 86 ar1 728 This article is online at http content 7 4 R769 2005 Keith et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The human leukocyte antigen B27 HLA-B27 transgenic rat is a model of human inflammatory bowel disease rheumatoid arthritis and psoriasis. Studies of chronic inflammation in other rat models have demonstrated activation of the kallikrein-kinin system as well as modulation by a plasma kallikrein inhibitor initiated before the onset of clinicopathologic changes or a deficiency in high-molecular-mass kininogen. Here we study the effects of monoclonal antibody C11C1 an antibody against high-molecular-mass kininogen that inhibits the binding of high-molecular-mass kininogen to leukocytes and endothelial cells in the HLA-B27 rat which was administered after the onset of the inflammatory changes. Thrice-weekly intraperitoneal injections of monoclonal antibody C11C1 or isotype IgG1 were given to male 23-week-old rats for 16 days. Stool character as a measure of intestinal inflammation and the rear limbs
