Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Negative regulation of cytokine signaling and immune responses by SOCS proteins. | Arthritis Research Therapy June 2005 Vol 7 No 3 Yoshimura et al. Review Negative regulation of cytokine signaling and immune responses by SOCS proteins Akihiko Yoshimura Hitomi Nishinakamura Yumiko Matsumura and Toshikatsu Hanada Division of Molecular and Cellular Immunology Medical Institute of Bioregulation Kyushu University Fukuoka Japan Corresponding author Akihiko Yoshimura yakihiko@ Published 30 March 2005 This article is online at http content 7 3 100 2005 BioMed Central Ltd Arthritis Research Therapy 2005 7 100-110 DOI ar1741 Abstract Immune and inflammatory systems are controlled by multiple cytokines including interleukins and interferons. Many of these cytokines exert their biological functions through JAKs Janus tyrosine kinases and STAT signal transduction and activators of transcription transcription factors. CIS cytokine-inducible SH2 Src homology 2 protein and SOCS suppressor of cytokine signaling are a family of intracellular proteins several of which have emerged as key physiological regulators of cytokine-mediated homeostasis including innate and adaptive immunity. In this review we focus on the molecular mechanism of the action of CIS SOCS family proteins and their roles in immune regulation and inflammatory diseases including rheumatoid arthritis. Introduction Cytokines regulate many physiological responses and homeostasis influencing the survival proliferation differentiation and functional activity of cells of the immune system as well as those of most other organ systems 1 . Cytokines including interleukins IFNs and hemopoietins activate the Janus kinases JAK1 JAK2 JAK3 and Tyk2 that associate with their cognate receptors. Activated JAKs phosphorylate the receptor cytoplasmic domains that create docking sites for Src homology 2 SH2 -containing signaling proteins. Among the substrates of tyrosine phosphorylation are members of the signal transducers and activators of transcription family of
