Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation. | Available online http content 7 4 R807 Research article The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation Julia J Inglis1 Ahuva Nissim1 Delphine M Lees2 Stephen P Hunt3 Yuti Chernajovsky1 and Bruce L Kidd1 1Bone and Joint Research Unit Barts and The London School of Medicine and Dentistry John Vane Science Centre London UK Experimental Therapeutics Barts and The London School of Medicine and Dentistry John Vane Science Centre London UK 3Department of Anatomy and Developmental Biology University College London London UK Corresponding author Bruce L Kidd Received 5 Oct 2004 Revisions requested 3 Dec 2004 Revisions received 21 Feb 2005 Accepted 16 Mar 2005 Published 12 Apr 2005 Arthritis Research Therapy 2005 7 R807-R816 DOI 86 ar1 743 This article is online at http content 7 4 R807 2005 Inglis et al. licensee BioMed Central Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Therapies directed against tumour necrosis factor TNF are effective for the treatment of rheumatoid arthritis and reduce pain scores in this condition. In this study we sought to explore mechanisms by which TNF contributes to inflammatory pain in an experimental model of arthritis. The effects of an anti-TNF agent etanercept on behavioural pain responses arising from rat monoarthritis induced by complete Freund s adjuvant were assessed and compared with expression of TNF receptors TNFRs by dorsal root ganglion DRG cells at corresponding time points. Etanercept had no effect on evoked pain responses in normal animals but exerted a differential effect on the thermal and mechanical hyperalgesia associated with rat arthritis
