Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin . | Arthritis Research Therapy June 2005 Vol 7 No 3 Sampey et al. Commentary Microsomal prostaglandin E synthase-1 the inducible synthase for prostaglandin E2 Annaleise V Sampey1 Seetha Monrad1 and Leslie J Crofford2 1 University of Michigan Ann Arbor MI USA 2University of Kentucky Lexington KY USA Corresponding author Leslie J Crofford lcrofford@ Published 6 April 2005 This article is online at http content 7 3 114 2005 BioMed Central Ltd Arthritis Research Therapy 2005 7 114-117 DOI ar1748 Abstract Microsomal prostaglandin E synthase-1 mPGES-1 is an inducible enzyme that catalyzes the conversion of prostaglandin PG H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of mPGES-1 in the increased local production of PGE2 observed in inflammatory arthritis. The focus of this article is to review some recent advances in our understanding of mechanisms specific to the regulation of inducible mPGES-1 in inflammatory arthritis. Introduction Prostaglandin PG E2 is the pivotal eicosanoid involved in the development and perpetuation of inflammation seen in diseases such as rheumatoid arthritis. In this disease local inflammation of synovial tissue is characterized in part by increased local levels of PG predominantly PGE2 1 . In the eicosanoid pathway induction of PGE2 biosynthesis during inflammation requires the enzymatic actions of two cytokineinducible enzymes cyclooxygenase COX and prostaglandin E synthase PGES Fig. 1 . An important role for COX-2 in producing PG in patients with inflammatory arthritis has been clearly shown in clinical trials that demonstrate equal efficacy of specific COX-2 inhibitors and nonspecific nonsteroidal antiinflammatory drugs NSAIDs 2 . Whether a similar essential role exists for the inducible microsomal prostaglandin E synthase-1 .
