Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Characterization of histopathology and gene-expression profiles of synovitis in early rheumatoid arthritis using targeted biopsy specimens. | Available online http content 7 4 R825 Research article Characterization of histopathology and gene-expression profiles of synovitis in early rheumatoid arthritis using targeted biopsy specimens Takahito Tsubaki1 Norimasa Arita1 Takuma Kawakami2 Takayuki Shiratsuchi2 Haruyasu Yamamoto1 Nobuo Takubo3 Kazuhito Yamada3 Sanpei Nakata3 Sumiki Yamamoto3 and Masato Nose1 Open Access 1Ehime University School of Medicine Ehime Japan 2Otsuka Pharmaceutical Co Ltd Tokushima Japan 3Center for Rheumatic Diseases Matsuyama Red Cross Hospital Ehime Japan Corresponding author Masato Nose masanose@ Received 30 Sep 2004 Revisions requested 27 Oct 2004 Revisions received 17 Mar 2005 Accepted 29 Mar 2005 Published 25 Apr 2005 Arthritis Research Therapy 2005 7 R825-R836 DOI 86 ar1 751 This article is online at http content 7 4 R825 2005 Tsubaki et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The disease category of early rheumatoid arthritis RA has been limited with respect to clinical criteria. Pathological manifestations of synovitis in patients whose disease is clinically classified as early RA seem to be heterogeneous with regular variations. To clarify the relation between the molecular and histopathological features of the synovitis we analyzed geneexpression profiles in the synovial lining tissues to correlate them with histopathological features. Synovial tissues were obtained from knee joints of 12 patients with early RA by targeted biopsy under arthroscopy. Surgical specimens of long-standing RA from four patients were examined as positive controls. Each histopathological parameter characteristic of rheumatoid synovitis in synovial tissues was scored .
