Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis. | Available online http content 7 4 R852 Research article Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis Allan A Young1 Margaret M Smith1 Susan M Smith1 Martin A Cake2 Peter Ghosh1 Richard A Read2 James Melrose1 David H Sonnabend1 Peter J Roughley3 and Christopher B Little1 1Raymond Purves Research Laboratory Institute of Bone and Joint Research Royal North Shore Hospital University of Sydney St Leonards New South Wales Australia 2School of Veterinary and Biomedical Sciences Murdoch University Perth Western Australia Australia 3Genetics Unit Shriners Hospital for Children Montreal Quebec Canada Corresponding author Allan A Young al_young@ Received 23 Jan 2005 Revisions requested 16 Feb 2005 Revisions received 9 Apr 2005 Accepted 14 Apr 2005 Published 12 May 2005 Arthritis Research Therapy 2005 7 R852-R861 DOI 86 ar1 756 This article is online at http content 7 4 R852 2005 Young et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Osteoarthritis OA the commonest form of arthritis and a major cause of morbidity is characterized by progressive degeneration of the articular cartilage. Along with increased production and activation of degradative enzymes altered synthesis of cartilage matrix molecules and growth factors by resident chondrocytes is believed to play a central role in this pathological process. We used an ovine meniscectomy model of OA to evaluate changes in chondrocyte expression of types I II and III collagen aggrecan the small leucine-rich proteoglycans SLRPs biglycan decorin lumican and fibromodulin transforming growth factor-P and connective .
