Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Reliability of computerized image analysis for the evaluation of serial synovial biopsies in randomized controlled trials in rheumatoid arthritis. | Available online http content 7 4 R862 Research article Reliability of computerized image analysis for the evaluation of serial synovial biopsies in randomized controlled trials in rheumatoid arthritis Jasper J Haringman1 Marjolein Vinkenoog1 Danielle M Gerlag1 Tom JM Smeets1 Aeilko H Zwinderman2 and Paul P Tak1 Division of Clinical Immunology and Rheumatology Academic Medical Center University of Amsterdam The Netherlands 2Department of Clinical Epidemiology and Biostatistics Academic Medical Center University of Amsterdam The Netherlands Corresponding author Paul PTak Received 14 Sep 2004 Revisions requested 4 Nov 2004 Revisions received 13 Apr 2005 Accepted 14 Apr 2005 Published 12 May 2005 Arthritis Research Therapy 2005 7 R862-R867 DOI 86 ar1 757 This article is online at http content 7 4 R862 2005 Haringman et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Analysis of biomarkers in synovial tissue is increasingly used in the evaluation of new targeted therapies for patients with rheumatoid arthritis RA . This study determined the intrarater and inter-rater reliability of digital image analysis DIA of synovial biopsies from RA patients participating in clinical trials. Arthroscopic synovial biopsies were obtained before and after treatment from 19 RA patients participating in a randomized controlled trial with prednisolone. Immunohistochemistry was used to detect CD3 T cells CD38 plasma cells and CD68 macrophages. The mean change in positive cells per square millimetre for each marker was determined by different operators and at different times using DIA. Nonparametric tests were used to determine differences between .
