Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Perforin deficiency attenuates collagen-induced arthritis. | Available online http content 7 4 R877 Research article Perforin deficiency attenuates collagen-induced arthritis Kristin Bauer1 Annika Knipper1 Hoang Tu-Rapp1 Dirk Koczan1 Hans-Jurgen Kreutzer2 Horst Nizze2 Eilhard Mix3 Hans-Juergen Thiesen1 Rikard Holmdahl4 and Saleh M Ibrahim1 institute of Immunology University of Rostock Rostock Germany institute of Pathology University of Rostock Rostock Germany institute of Neurology University of Rostock Rostock Germany 4Section for Medical Inflammation Research Lund University Lund Sweden Corresponding author Saleh M Ibrahim Received 24 Sep 2004 Revisions requested 14 Oct 2004 Revisions received 22 Mar 2005 Accepted 15 Apr 2005 Published 20 May 2005 Arthritis Research Therapy 2005 7 R877-R884 DOI 86 ar1 758 This article is online at http content 7 4 R877 2005 Bauer et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Collagen-induced arthritis CIA an approved animal model for rheumatoid arthritis is thought to be a T cell-dependent disease. There is evidence that CD8 T cells are a major subset controlling the pathogenesis of CIA. They probably contribute to certain features of disease namely tissue destruction and synovial hyperplasia. In this study we examined the role of perforin pfp a key molecule of the cytotoxic death pathway that is expressed mainly in CD8 T cells for the pathogenesis of CIA. We generated DBA 1J mice suffering from mutations of the pfp molecule DBA 1J-pfp- - and studied their susceptibility to arthritis. As a result pfp-deficient mice showed a reduced incidence DBA 1J-pfp 64 DBA U-pfp 54 a slightly delayed onset onset of disease DBA 1 J-pfp 53 DBA .
