Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Screening of an endothelial cDNA library identifies the C-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with psychiatric manifestations. | Available online http content 7 4 R896 Research article Screening of an endothelial cDNA library identifies the C-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with psychiatric manifestations Paola Margutti1 Maurizio Sorice2 Fabrizio Conti3 Federica Delunardo1 Mauro Racaniello1 Cristiano Alessandri3 Alessandra Siracusano1 Rachele Riganò1 Elisabetta Profumo1 Guido Valesini3 and Elena Ortona1 Open Access 1Dipartimento di Malattie Infettive Parassitarie e Immunomediate Istituto Superiore di Sanità Rome Italy 2Dipartimento di Medicina Sperimentale e Patologia Cattedra di Reumatologia Università La Sapienza Rome Italy 3Dipartimento di Clinica e Terapia Medica Applicata Cattedra di Reumatologia Università La Sapienza Rome Italy Corresponding author Elena Ortona ortona@ Received 23 Dec 2004 Revisions requested 20 Jan 2005 Revisions received 22 Mar 2005 Accepted 18 Apr 2005 Published 20 May 2005 Arthritis Research Therapy 2005 7 R896-R903 DOI 86 ar1 759 This article is online at http content 7 4 R896 2005 Margutti et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Anti-endothelial-cell antibodies are associated with psychiatric manifestations in systemic lupus erythematosus SLE . Our primary aim in this study was to seek and characterize molecules that behave as endothelial autoantigens in SLE patients with psychiatric manifestations. By screening a cDNA library from human umbilical artery endothelial cells with serum from an SLE patient with psychosis we identified one positive strongly reactive clone encoding the C-terminal region C-ter of Nedd5 an intracytoplasmatic protein of the septin family. To evaluate anti-Nedd5 serum .
