Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Aetiology and pathogenesis of reactive arthritis: role of non-antigen-presenting effects of HLA-B27. | Arthritis Research Therapy August 2005 Vol 7 No 4 Văhămiko et al. Review Aetiology and pathogenesis of reactive arthritis role of non-antigen-presenting effects of HLA-B27 Sanna Văhămiko Markus A Penttinen and Kaisa Granfors Department of Bacterial and Inflammatory Diseases National Public Health Institute Turku Finland Corresponding author Kaisa Granfors Published 26 May 2005 This article is online at http content 7 4 136 2005 BioMed Central Ltd Arthritis Research Therapy 2005 7 136-141 DOI ar1762 Abstract Spondyloarthropathies are inflammatory diseases closely associated with human leukocyte antigen HLA -B27 by unknown mechanisms. One of these diseases is reactive arthritis ReA which is typically triggered by Gram-negative bacteria which have lipopolysaccharide as an integral component of their outer membrane. Several findings in vivo and in vitro obtained from patients with ReA and from different model systems suggest that HLA-B27 modulates the interaction between ReA-triggering bacteria and immune cells by a mechanism unrelated to the antigen presentation function of HLA-B27. In this review we piece together a jigsaw puzzle from the new information obtained from the non-antigen-presenting effects of HLA-B27. Introduction The association between a group of rheumatic diseases called spondyloarthropathies SpA and human leukocyte antigen HLA -B27 has been known for several decades 1 2 . Several theories have been proposed to clarify the pathogenic role of HLA-B27 3-7 many of them based on the idea that classical function of HLA-B27 antigen presentation to T cells is somehow abnormal and leads to the development of inflammatory diseases. However the proposed theories about altered antigen presenting effects of HLA-B27 have not yielded a widely accepted and comprehensive explanation of the association of HLA-B27 and SpA. Reactive arthritis ReA is an acute inflammatory joint disease belonging to the group of SpA. .
