Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis. | Available online http content 7 4 R904 Research article Catabolic stress induces expression of hypoxia-inducible factor HIF -1 a in articular chondrocytes involvement of HIF-1a in the pathogenesis of osteoarthritis Kazuo Yudoh Hiroshi Nakamura Kayo Masuko-Hongo Tomohiro Kato and Kusuki Nishioka Department of Bioregulation Institute of Medical Science St. Marianna University School of Medicine Kawasaki Japan Corresponding author Kazuo Yudoh yudo@ Received 20 Nov 2004 Revisions requested 16 Dec 2004 Revisions received 23 Apr 2005 Accepted 5 May 2005 Published 27 May 2005 Arthritis Research Therapy 2005 7 R904-R914 DOI 86 ar1 765 This article is online at http content 7 4 R904 2005 Yudoh et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Transcription factor hypoxia-inducible factor HIF -1 protein accumulates and activates the transcription of genes that are of fundamental importance for oxygen homeostasis - including genes involved in energy metabolism angiogenesis vasomotor control apoptosis proliferation and matrix production - under hypoxic conditions. We speculated that HIF-1a may have an important role in chondrocyte viability as a cell survival factor during the progression of osteoarthritis OA . The expression of HIF-1 a mRNA in human OA cartilage samples was analyzed by real-time PCR. We analyzed whether or not the catabolic factors IL-1P and H2O2 induce the expression of HIF-1a in OA chondrocytes under normoxic and hypoxic conditions O2 6 . We investigated the levels of energy generation cartilage matrix production and apoptosis induction in HIF-1a-deficient chondrocytes under normoxic and hypoxic conditions. In articular .
