Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Accelerated development of arthritis in mice lacking endothelial selectins. | Available online http content 7 5 R959 Research article Accelerated development of arthritis in mice lacking endothelial selectins Jeffrey H Ruth1 2 M Asif Amin1 2 James M Woods1 3 Xiaodong He4 Sharon Samuel4 Nengjun Yi5 Christian S Haas1 2 Alisa E Koch1 2 6 7 and Daniel C Bullard4 Open Access Northwestern University Feinberg School of Medicine Chicago Illinois USA 2University of Michigan Medical School Ann Arbor Michigan USA 3Midwestern University Downers Grove Illinois USA 4Department of Genetics University of Alabama at Birmingham Birmingham Alabama USA 5Department of Biostatistics University of Alabama at Birmingham Birmingham Alabama USA 6Veteran s Administration Chicago Health Care Medical Center Lakeside Division Chicago Illinois USA 7Ann Arbor Veteran s Administration Ann Arbor Michigan USA Contributed equally Corresponding author Alisa E Koch aekoch@ Received 10 Nov 2004 Revisions requested 7 Dec 2004 Revisions received 1 2 May 2005 Accepted 17 May 2005 Published 15 Jun 2005 Arthritis Research Therapy 2005 7 R959-R970 DOI 86 ar1 770 This article is online at http content 7 5 R959 2005 Ruth et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The selectins along with very late antigen-4 and CD44 have been implicated in mediating leukocyte rolling interactions that lead to joint recruitment and inflammation during the pathogenesis of rheumatoid arthritis. Previously we showed that P-selectin deficiency in mice resulted in accelerated onset of joint inflammation in the murine collagen-immunized arthritis model. Here we report that mice deficient either in E-selectin or in E-selectin and P-selectin E P-selectin mutant also exhibit accelerated .
