Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Altered dendritic cell distribution in patients with common variable immunodeficiency. | Available online http content 7 5 R1052 Research article Altered dendritic cell distribution in patients with common variable immunodeficiency Jean-Franọois Viallard1 Fabrice Camou1 Marc André2 Franpois Liferman3 Jean-Franọois Moreau4 Jean-Luc Pellegrin1 and Patrick Blanco4 Open Access Department of Internal Medicine and Infectious Diseases Haut-Lévêque Hospital Pessac France 2Department of Internal Medicine Gabriel-Montpied Hospital Clermont-Ferrand France 3Department of Internal Medicine Dax Hospital Dax France 4Laboratory of Immunology Pellegrin Hospital Bordeaux France Corresponding author Jean-Franọois Viallard Received 14 Jan 2005 Revisions requested 1 7 Feb 2005 Revisions received 23 May 2005 Accepted 1 Jun 2005 Published 1 Jul 2005 Arthritis Research Therapy 2005 7 R1052-R1055 DOI ar1774 This article is online at http content 7 5 R1052 2005 Viallard et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Recent data suggest a critical role for dendritic cells DCs in the generation of immunoglobulin-secreting plasma cells. In the work reported herein we analyzed the frequency of peripheral blood plasmacytoid DCs pDCs and myeloid DCs mDCs in a cohort of 44 adults with common variable immunodeficiency CVID classified according to their CD27 membrane expression status on B cells. A deep alteration in the distribution of DC subsets especially of pDCs in the peripheral blood of CVID patients was found. Patients with a reduced number of class-switched CD27 IgD IgM memory B cells and patients with granulomatous disease had a dramatic decrease in pDCs P and vs controls respectively and to a lesser extent of .
