Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Local hyperhemia to heating is impaired in secondary Raynaud's phenomenon. | Available online http content 7 5 R1103 Research article Local hyperhemia to heating is impaired in secondary Raynaud s phenomenon Aude Boignard1 2 Muriel Salvat-Melis1 2 Patrick H Carpentier3 Christopher T Minson4 Laurent Grange5 Catherine Duc5 Frangoise Sarrot-Reynauld6 and Jean-Luc Cracowski1 2 Laboratory HP2 EA 3745 Inserm ESPRI Grenoble Medical School France 2Inserm Clinical Research Center 03 Grenoble University Hospital Grenoble France 3Vascular Medicine Department Grenoble University Hospital Grenoble France 4Department of Human Physiology University of Oregon Eugene Oregon USA 5Department of Rheumatology Grenoble University Hospital Grenoble France 6Internal Medicine Department Grenoble University Hospital Grenoble France Corresponding author Jean-Luc Cracowski Received 17 May 2005 Revisions requested 7 Jun 2005 Revisions received 8 Jun 2005 Accepted 13 Jun 2005 Published 19 Jul 2005 Arthritis Research Therapy 2005 7 R1103-R1112 DOI ar1785 This article is online at http content 7 5 R1103 2005 Boignard et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Accurate and sensitive measurement techniques are a key issue in the quantification of the microvascular and endothelial dysfunction in systemic sclerosis SSc . Thermal hyperhemia comprises two separate mechanisms an initial peak that is axon reflex mediated and a sustained plateau phase that is nitric oxide dependent. The main objective of our study was to test whether thermal hyperhemia in patients with SSc differed from that in patients with primary Raynaud s phenomenon RP and healthy controls. In a first study we enrolled 20 patients suffering from SSc
