Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases. | Available online http content 7 5 R1091 Research article The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors MMP-13 cathepsin K and aggrecanases Jean-Pierre Pelletier1 Christelle Boileau1 Martin Boily1 Julie Brunet1 Franpois Mineau1 Changshen Geng1 Pascal Reboul1 Stefan Laufer2 Daniel Lajeunesse1 and Johanne Martel-Pelletier1 Open Access Osteoarthritis Research Unit University of Montreal Hospital Centre Notre-Dame Hospital Montreal Quebec Canada 2Department of Pharmaceutical Chemistry Medicinal Chemistry Eberhard-Karls-University Tubingen Institute of Pharmacy Tubingen Germany Corresponding author Jean-Pierre Pelletier dr@ Received 22 Dec 2004 Revisions requested 3 Feb 2005 Revisions received 6 Jun 2005 Accepted 17 Jun 2005 Published 19 Jul 2005 Arthritis Research Therapy 2005 7 R1091-R1102 DOI ar1788 This article is online at http content 7 5 R1091 2005 Pelletier et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract This study sought to evaluate the levels of mRNA expression and protein synthesis of MMP-13 cathepsin K aggrecanase-1 ADAMTS-4 aggrecanase-2 ADAMTS-5 and 5-lipoxygenase 5-LOX in cartilage in the experimental anterior cruciate ligament ACL dog model of osteoarthritis OA and to examine the effects of treatment with licofelone a 5-lipoxygenase LOX cyclooxygenase COX inhibitor on the levels of these catabolic factors. Sectioning of the ACL of the right knee was performed in three experimental groups group 1 received no active treatment placebo group and groups 2 and 3 received therapeutic .
