Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis. | Available online http content 7 6 R1158 Research article Expression of ADAM15 in rheumatoid synovium up-regulation by vascular endothelial growth factor and possible implications for angiogenesis Koichiro Komiya1 2 Hiroyuki Enomoto2 Isao Inoki1 Satoko Okazaki1 Yoshinari Fujita1 2 Eiji Ikeda1 Eiko Ohuchi3 Hideo Matsumoto2 Yoshiaki Toyama2 and Yasunori Okada1 Open Access Department of Pathology School of Medicine Keio University Shinjuku-ku Tokyo Japan 2Department of Orthopaedic Surgery School of Medicine Keio University Shinjuku-ku Tokyo Japan 3Biopharmaceutical Department Daiichi Fine Chemical Co. Ltd. Takaoka Toyama Japan Corresponding author Yasunori Okada okada@ Received 28 May 2005 Revisions requested 20 Jun 2005 Revisions received 23 Jun 2005 Accepted 27 Jun 2005 Published 5 Aug 2005 Arthritis Research Therapy 2005 7 R1158-R1173 DOI ar1796 This article is online at http content 7 6 R1158 2005 Komiya et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract ADAMs a disintegrin and metalloproteinases comprise a new gene family of metalloproteinases and may play roles in cell-cell interaction cell migration signal transduction shedding of membrane-anchored proteins and degradation of extracellular matrix. We screened the mRNA expression of 10 different ADAMs with a putative metalloproteinase motif in synovial tissues from patients with rheumatoid arthritis RA or osteoarthritis OA . Reverse transcription PCR and real-time quantitative PCR analyses indicated that among the ADAMs ADAM15 mRNA was more frequently expressed in the RA samples and its expression level was significantly higher in RA than in OA p . In situ hybridization .
