Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Reconstitution of the adult B cell repertoire after treatment with rituximab. | Available online http contents 7 5 175 Commentary Reconstitution of the adult B cell repertoire after treatment with rituximab Inaki Sanz and Jennifer Anolik Division of Clinical Immunology Rheumatology University of Rochester School of Medicine and Dentistry Rochester New York USA Corresponding author Inaki Sanz Ignacio_Sanz@ Published 22 July 2005 Arthritis Research Therapy 2005 7 175-176 DOI ar1799 This article is online at http content 7 5 175 2005 BioMed Central Ltd See related research by Rouziere et al. http content 7 4 R714 Abstract B cells play diverse and fundamental roles in the pathogenesis of autoimmune diseases. Consequently therapeutic targeting of B cells is gaining prominence in our clinical armamentarium for an ever expanding array of autoimmune and neoplastic disorders. Therefore it is of great importance to understand the mechanism of action of B cell depletion. Given that the ideal consequence of B cell depletion would be the subsequent re-establishment of immunologic tolerance a detailed analysis of the properties of the emerging repertoire will be required. The results presented by Rouziere and coworkers in their study of rheumatoid arthritis patients shed some light on this question and are discussed in this commentary. As reflected in the work by Rouziere and coworkers 1 B cells have become a major therapeutic target for autoimmune diseases. This prominence stems from two convergent developments. One of these is the understanding that in addition to conventional antibody dependent effects B cells also play important regulatory and potentially pathogenic roles through antibody independent mechanisms including antigen presentation T cell activation and polarization dendritic cell regulation and cytokine and chemokine production 2 . Moreover mounting clinical evidence strongly supports the therapeutic benefit of targeting B cells in an array of .
