Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats. | Available online http content 7 6 R1174 Research article Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats Atsushi Omoto1 Yutaka Kawahito1 Igor Prudovsky2 Yasunori Tubouchi1 Mizuho Kimura1 Hidetaka Ishino1 Makoto Wada1 Makie Yoshida1 Masataka Kohno1 Rikio Yoshimura3 Toshikazu Yoshikawa1 and Hajime Sano4 inflammation and Immunology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan 2Center for Molecular Medicine Maine Medical Center Research Institute Scarborough Maine USA 3Department of Urology Osaka City Graduate School of Medicine Osaka Japan 4Division of Rheumatology and Clinical Immunology Department of Internal Medicine Hyogo College of Medicine Nishinomiya Japan Corresponding author Yutaka Kawahito kawahity@ Received 15 Mar 2005 Revisions requested 11 Apr 2005 Revisions received 9 Jun 2005 Accepted 7 Jul 2005 Published 8 Aug 2005 Arthritis Research Therapy 2005 7 R1174-R1182 DOI ar1801 This article is online at http content 7 6 R1174 2005 Omoto et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Tetrathiomolybdate TM a drug developed for Wilson s disease produces an anti-angiogenic and anti-inflammatory effect by reducing systemic copper levels. TM therapy has proved effective in inhibiting the growth of tumors in animal tumor models and in cancer patients. We have hypothesized that TM may be used for the therapy of rheumatoid arthritis and have examined the efficacy of TM on adjuvant-induced arthritis in the rat which is a model of acute inflammatory arthritis and inflammatory cachexia. TM delayed the onset of and .
