Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: A functional variant of Fcγ receptor IIIA is associated with rheumatoid arthritis in individuals who are positive for anti-glucose-6-phosphate isomerase antibodies. | Available online http content 7 6 R1183 Research article A functional variant of Fcy receptor IIIA is associated with rheumatoid arthritis in individuals who are positive for anti-glucose-6-phosphate isomerase antibodies Isao Matsumoto1 2 Hua Zhang1 2 Yoshifumi Muraki1 Taichi Hayashi1 Takanori Yasukochi1 2 Yuko Kori1 Daisuke Goto1 Satoshi Ito1 Akito Tsutsumi1 and Takayuki Sumida1 Clinical Immunology University of Tsukuba University of Tsukuba Ibaraki Japan 2PRESTO Japan Science and Technology Agency Saitama Japan Contributed equally Corresponding author Isao Matsumoto ismatsu@ Received 4 Feb 2005 Revisions requested 15 Mar 2005 Revisions received 4 Jul 2005 Accepted 19 Jul 2005 Published 11 Aug 2005 Arthritis Research Therapy 2005 7 R1183-R1188 DOI ar1802 This article is online at http content 7 6 R1183 2005 Matsumoto et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Anti-glucose-6-phosphate isomerase GPI antibodies are known to be arthritogenic autoantibodies in K BxN mice although some groups have reported that few healthy humans retain these antibodies. The expression of Fcy receptors FcyRs is genetically regulated and has strong implications for the development of experimental arthritis. The interaction between immune complexes and FcyRs might therefore be involved in the pathogenesis of some arthritic conditions. To explore the relationship between functional polymorphisms in FcyRs FCGR3A-158V F and FCGR2A-131H R and arthritis in individuals positive for anti-GPI antibodies we evaluated these individuals with respect to FCGR genotype. Genotyping for FCGR3A-158V F and FCGR2A-131 H R was performed by PCR amplification of the .
