Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Primary and secondary autoimmune neutropenia. | Arthritis Research Therapy October 2005 Vol 7 No 5 Capsoni et al. Review Primary and secondary autoimmune neutropenia Franco Capsoni1 Piercarlo Sarzi-Puttini2 and Alberto Zanella3 1 Rheumatology Unit Istituto Ortopedico Galeazzi University of Milan Milan Italy 2Rheumatology Unit Ospedale L Sacco University of Milan Milan Italy 3Hematology Unit Ospedale Maggiore Policlinico Fondazione IRCCS University of Milan Milan Italy Corresponding author Franco Capsoni Published 31 August 2005 This article is online at http content 7 5 208 2005 BioMed Central Ltd Arthritis Research Therapy 2005 7 208-214 DOI ar1803 Abstract Antineutrophil antibodies are well recognized causes of neutropenia producing both quantitative and qualitative defects in neutrophils and increased risk for infection. In primary autoimmune neutropenia AIN of infancy a moderate to severe neutropenia is the sole abnormality it is rarely associated with serious infections and exhibits a self-limited course. Chronic idiopathic neutropenia of adults is characterized by occurrence in late childhood or adulthood greater prevalence among females than among males and rare spontaneous remission. Secondary AIN is more commonly seen in adults and underlying causes include collagen disorders drugs viruses and lymphoproliferative disorders. In most patients with AIN antibodies recognize antigens located on the IgG Fc receptor type 3b but other target antigens have been recently identified in secondary AIN. Granulocyte colonystimulating factor is a proven treatment in patients with AIN of all types and is now preferred to other possible therapies. Introduction The term neutropenia is used to define a condition in which circulating neutrophils number less than 1500 ựl. Neutropenias can be classified according to the mechanism of induction and so there are forms due to decreased production of neutrophils to sequestering of neutrophils from endothelial or tissue pools .
