Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Clinical and laboratory characteristics of drug-induced vasculitic syndromes Allan Wiik. | Available online http content 7 5 191 Commentary Clinical and laboratory characteristics of drug-induced vasculitic syndromes Allan Wiik Department of Autoimmunology Statens Serum Institut Copenhagen Denmark Corresponding author Allan Wiik aw@ Published 24 August 2005 Arthritis Research Therapy 2005 7 191-192 DOI ar1805 This article is online at http eontent 7 5 2005 BioMed Central Ltd See related research by Bonaci-Nikolic et al. in this issue http eontent 7 5 R1072 Abstract Clinical recognition of drug-induced vasculitic and lupus-like syndromes is very important because continued use of the offending drug can lead to irreversible and life-threatening vasculitic organ damage . end-stage renal disease or pulmonary haemorrhage . Withdrawal of the drug often leads to spontaneous recovery meaning that immunosuppressive therapy can be avoided. The presence of myeloperoxidase-antineutrophil cytoplasmic antibodies IgM anticardiolipin antibody and antihistone antibodies in combination was found to be characteristic of drug-induced vasculitic syndromes caused by the antithyroid drugs propylthiouracil and methimazol. Clinically skin vasculitis and arthralgias predominated and renal vasculitis was rare. Introduction The differential diagnosis between drug-induced and idiopathic vasculitic conditions may be difficult in the individual patient. Because the mere withdrawal of the offending drug in the former situation is usually sufficient to attain complete remission of clinical symptoms the distinction between these syndromes is very important. Failure to recognize a relationship with a drug can lead to fatal organ damage. The report by Branka Bonaci-Nikolic and coworkers 1 included in this issue of Arthritis Research and Therapy is a good example of clinical research aimed at identifying details that can aid in distinguishing between seemingly related syndromes such as idiopathic .
