Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor 22-620W allele. | Available online http content 7 6 R1200 Research article Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor 22-620W allele Philippe Dieudé1 2 Sophie Garnier1 Laetitia Michou1 Elisabeth Petit-Teixeira1 Elodie Glikmans1 Céline Pierlot1 Sandra Lasbleiz1 2 Thomas Bardin1 2 Bernard Prum3 Franọois Cornélis1 2 4 for the European Consortium on Rheumatoid Arthritis Families 1GenHotel-EA3886 Evry-Genopole Evry France 2Unité de Génétique Clinique Fédération de Rhumatologie Centre Viggo-Petersen Hôpital Lariboisière Assistance Publique des Hôpitaux de Paris Paris France 3Laboratoire Statistique et Génome Evry-Genopole Evry France 4Consultation de Génétique Adulte Centre Hospitalier Sud-Francilien Evry-Corbeil France Corresponding author Philippe Dieudé dieude@ Received 1 4 May 2005 Revisions requested 21 Jun 2005 Revisions received 15 Jul 2005 Accepted 4 Aug 2005 Published 25 Aug 2005 Arthritis Research Therapy 2005 7 R1200-R1 207 DOI ar1812 This article is online at http content 7 6 R1 200 2005 Dieudé et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The protein tyrosine phosphatase nonreceptor type 22 PTPN22 gene encodes for lymphoid tyrosine phosphatase LYP involved in the negative regulation of early T-cell activation. An association has recently been reported between the PTPN22-620W functional allele and rheumatoid factor-positive RF rheumatoid arthritis RA among other autoimmune diseases. Expected linkage proof for consistency cannot be definitely produced by an affected sib-pair ASP analysis. Our aim was therefore to search for linkage evidence with the transmission .
