Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Absence of autoantibodies against correctly folded recombinant fibrillin-1 protein in systemic sclerosis patients. | Available online http content 7 6 R1221 Research article Absence of autoantibodies against correctly folded recombinant fibrillin-1 protein in systemic sclerosis patients Jurgen Brinckmann1 Nico Hunzelmann2 Ehab El-Hallous3 Thomas Krieg2 Lynn Y Sakai4 Sven Krengel1 and Dieter P Reinhardt5 Department of Dermatology University of Lubeck Lubeck Germany 2Department of Dermatology University of Cologne Cologne Germany 3Department of Medical Molecular Biology University of Lubeck Lubeck Germany 4Department of Biochemistry and Molecular Biology and Shriners Hospital for Children Oregon Health and Science University Portland OR USA 5Department of Anatomy and Cell Biology and Faculty of Dentistry McGill University Montreal Canada Corresponding author Jurgen Brinckmann brinckmann@ Received 1 Jun 2005 Revisions requested 23 Jun 2005 Revisions received 11 Jul 2005 Accepted 8 Aug 2005 Published 6 Sep 2005 Arthritis Research Therapy 2005 7 R1221-R1226 DOI ar1813 This article is online at http content 7 6 R1 221 2005 Brinckmann et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Autoantibodies against short recombinant fragments of fibrillin-1 produced in bacterial expression systems have been found in tight-skin mouse systemic sclerosis mixed connective tissue disease and primary pulmonary hypertension syndrome. In patients with scleroderma the frequency of anti-fibrillin-1 antibodies was 42 in Caucasians. Until now it has been unclear whether this immune response has a primary function in disease pathogenesis or is a secondary phenomenon. In the present study we analyzed the frequency of autoantibodies against two overlapping recombinant .
