Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells. | Available online http content 7 6 R1304 Research article Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells Farida Djouad1 Claire Bony1 Thomas Haupl2 Gilles Uzé3 Najiba Lahlou4 Pascale Louis-Plence1 Florence Apparailly1 Franpois Canovas5 Thierry Rème1 Jacques Sany5 Christian Jorgensen1 and Danièle Noel1 Open Access 1INSERM Unit 475 Montpellier France 2Rheumatology Charité Hospital Berlin Germany 3CNRS UMR 5124 Montpellier France 4Hormonal Biology Laboratory St Vincent de Paul Hospital Paris France 5Immuno-Rhumatologie Lapeyronie Hospital Montpellier France Corresponding author Danièle Noel noel@ Received 12 May 2005 Revisions requested 18 Jul 2005 Revisions received 26 Jul 2005 Accepted 24 Aug 2005 Published 20 Sep 2005 Arthritis Research Therapy 2005 7 R1304-R1315 DOI ar1827 This article is online at http content 7 6 R1304 2005 Djouad et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Previous studies have reported that mesenchymal stem cells MSC may be isolated from the synovial membrane by the same protocol as that used for synovial fibroblast cultivation suggesting that MSC correspond to a subset of the adherent cell population as MSC from the stromal compartment of the bone marrow BM . The aims of the present study were first to better characterize the MSC derived from the synovial membrane and second to compare systematically in parallel the MSC-containing cell populations isolated from BM and those derived from the synovium using quantitative assays. Fluorescent-activated cell sorting analysis revealed that both populations were negative for CD14 CD34 and CD45 expression and that both .
