Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Genetic mechanisms of knee osteoarthritis: a population-based longitudinal study. | Available online http content 8 1 R8 Research article Genetic mechanisms of knee osteoarthritis a population-based longitudinal study Changhai Ding 1 Flavia Cicuttini2 Leigh Blizzard1 and Graeme Jones1 1Menzies Research Institute University of Tasmania Hobart Australia 2Department of Epidemiology and Preventive Medicine Monash University Medical School Melbourne Australia Corresponding author Graeme Jones Received 10 Jun 2005 Revisions requested 29 Jul 2005 Revisions received 22 Aug 2005 Accepted 5 Sep 2005 Published 21 Nov 2005 Arthritis Research Therapy 2006 8 R8 doi ar1835 This article is online at http content 8 1 R8 2005 Ding et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract To describe the differences in knee structure and non-knee structural factors between offspring having at least one parent with a total knee replacement for severe primary knee osteoarthritis and age- and sex-matched controls with no family history of knee osteoarthritis a population-based longitudinal study of 163 matched pairs mean age 45 years range 26 to 61 was performed at baseline and about 2 years later. Knee cartilage defect score 0 to 4 cartilage volume and bone size were determined with T1-weighted fat saturation magnetic resonance imaging. Body mass index BMI lower-limb muscle strength knee pain physical work capacity at 170 beats minute PWC170 and radiographic osteoarthritis were measured by standard protocols. In comparison with controls offspring had higher annual knee cartilage loss versus at medial tibial site versus at lateral tibial site and versus at patellar site all P a greater increase in .
