Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis. | Available online http content 7 6 R1412 Research article Between adaptive and innate immunity TLR4-mediated perforin production by CD28nuH T-helper cells in ankylosing spondylitis Bernd Raffeiner1 Christian Dejaco1 Christina Duftner1 Werner Kullich2 Christian Goldberger1 Sandra C Vega3 Michael Keller3 Beatrix Grubeck-Loebenstein3 and Michael Schirmer1 Department of Internal Medicine Innsbruck Medical University Austria 2Ludwig Boltzmann Institute for Rehabilitation of Internal Diseases Saalfelden Austria 3Institute for Biomedical Aging Research Austrian Academy of Science Austria Contributed equally Corresponding author Michael Schirmer Received 21 Apr 2005 Revisions requested 14 Jun 2005 Revisions received 26 Aug 2005 Accepted 27 Sep 2005 Published 18 Oct 2005 Arthritis Research Therapy 2005 7 R141 2-R1420 DOI ar1840 This article is online at http content 7 6 R141 2 2005 Raffeiner et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract CD3 CD4 CD28nu and CD3 CD8 CD28nu T cells are enriched in patients with immune-mediated diseases compared with healthy controls. This study shows that CD4 CD28null T cells express Toll-like receptors recognizing bacterial lipopolysaccharides in ankylosing spondylitis psoriatic arthritis and rheumatoid arthritis. In ankylosing spondylitis TLR4 and to a smaller extent TLR2 were expressed on CD4 CD28null T cells whereas expression was negligible on CD4 CD28 and CD8 T cells. CD4 CD28nu T cells produced perforin upon stimulation with lipopolysaccharide and this effect was enhanced by autologous serum or recombinant soluble CD14. Perforin production could be prevented with .
