Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels. | Available online http content 8 1 R6 Open Access Research article B lymphocyte stimulator BLyS isoforms in systemic lupus erythematosus disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels Christopher E Collins1 Amanda L Gavin2 Thi-Sau Migone3 David M Hilbert3 David Nemazee2 and William Stohl1 Division of Rheumatology Department of Medicine Los Angeles County University of Southern California Medical Center and University of Southern California Keck School of Medicine 2011 Zonal Avenue Los Angeles CA 90033 USA 2Department of Immunology Scripps Research Institute 10550 North Torrey Pines Road La Jolla CA 92037 USA 3Human Genome Sciences Inc. 14200 Shady Grove Road Rockville MD 20850 USA Contributed equally Corresponding author William Stohl stohl@ Received 10 Aug 2005 Revisions requested 7 Sep 2005 Revisions received 23 Sep 2005 Accepted 20 Oct 2005 Published 15 Nov 2005 Arthritis Research Therapy 2006 8 R6 doi ar1855 This article is online at http content 8 1 R6 2005 Collins et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Considerable evidence points to a role for B lymphocyte stimulator BLyS overproduction in murine and human systemic lupus erythematosus SLE . Nevertheless the correlation between circulating levels of BLyS protein and disease activity in human SLE is modest at best. This may be due to an inadequacy of the former to reflect endogenous BLyS overproduction faithfully in that steady-state protein levels are affected not just by production rates but also by rates of peripheral utilization and excretion. Increased levels of BLyS mRNA may better reflect increased in vivo BLyS .
