Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype. | Available online http content 8 1 R13 Research article In adult onset myositis the presence of interstitial lung disease and myositis specific associated antibodies are governed by HLA class II haplotype rather than by myositis subtype Hector Chinoy1 2 Fiona Salway2 Noreen Fertig3 Neil Shephard4 Brian D Tait5 Wendy Thomson4 David A Isenberg6 Chester V Oddis3 Alan J Silman4 William ER Ollier2 Robert G Cooper1 and the UK Adult Onset Myositis Immunogenetic Collaboration AOMIC Rheumatic Diseases Centre Hope Hospital Salford UK 2Centre for Integrated Genomic Medical Research University of Manchester Manchester UK 3Division of Rheumatology and Clinical Immunology University of Pittsburgh School of Medicine Pittsburgh PA USA 4arc Epidemiology Research Unit University of Manchester Manchester UK 5Victorian Transplantation and Immunogenetic Service Australian Red Cross Blood Transfusion Service Melbourne Australia 6Centre for Rheumatology Department of Medicine University College London London UK Corresponding author Robert G Cooper Rcooper@fs1 . Received 22 Sep 2005 Revisions requested 12 Oct 2005 Revisions received 25 Oct 2005 Accepted 4 Nov 2005 Published 5 Dec 2005 Arthritis Research Therapy 2006 8 R13 doi ar1 862 This article is online at http content 8 1 R13 2005 Chinoy et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The aim of this study was to investigate HLA class II associations in polymyositis PM and dermatomyositis DM and to determine how these associations influence clinical and serological differences. DNA samples were obtained from 225 UK Caucasian idiopathic inflammatory myopathy patients PM 117 DM 108 and compared with 537
