Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus. | Available online http content 8 1 203 Review Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus Petar S Lenert Assistant Professor Division of Rheumatology Department of Internal Medicine Carver College of Medicine The University of Iowa Iowa City Iowa USA Corresponding author Petar S Lenert petar-lenert@ Published 10 January 2006 This article is online at http content 8 1 203 2006 BioMed Central Ltd Arthritis Research Therapy 2006 8 203 doi ar1888 Abstract This review focuses on the role of Toll-like receptors TLRs in lupus and on possibilities to treat lupus using TLR modulating inhibitory oligodeoxynucleotides INH-ODNs . TLRs bridge innate and adaptive immune responses and may play an important role in the pathogenesis of systemic lupus erythematosus. Of particular interest are TLR3 -7 -8 and -9 which are localized intracellularly. These TLRs recognize single-stranded or double-stranded RNA or hypomethylated CpG-DNA. Exposure to higher order CpG-DNA ligands or to immune complexed self-RNA triggers activation of autoreactive B cells and plasmacytoid dendritic cells. INH-ODNs were recently developed that block all downstream signaling events in TLR9-responsive cells. Some of these INH-ODNs can also target TLR7 signaling pathways. Based on their preferential cell reactivity we classify INH-ODNs into class B and class R. Class B broadly reactive INH-ODNs target a broad range of TLR-expressing cells. Class R restricted INH-ODNs easily form DNA duplexes or higher order structures and are preferentially recognized by autoreactive B cells and plasmacytoid dendritic cells rather than by non-DNA specific follicular B cells. Both classes of INH-ODNs can block animal lupus. Hence therapeutic application of these novel INH-ODNs in human lupus particularly class R INH-ODNs may result in more selective and diseasespecific immunosuppression. .