Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren's syndrome. | Available online http content 8 2 R51 Research article B cell-activating factor of the tumor necrosis factor family BAFF is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjogren s syndrome Marc Ittah1 Corinne Miceli-Richard1 Jacques- Eric Gottenberg1 Frédéric Lavie1 Thierry Lazure2 Nathalie Ba2 Jérémie Sellam1 Christine Lepajolec3 and Xavier Mariette1 1Rhumatologie Institut Pour la Santé et la Recherche Médicale INSERM U 802 Hôpital Bicêtre Assistance Publique-Hôpitaux de Paris AP-HP Université Paris-Sud 11 78 rue du Général Leclerc 94275 Le Kremlin Bicêtre France 2Anatomopathologie Hôpital de Bicêtre AP-HP 78 rue du Général Leclerc 94275 Le Kremlin Bicêtre France 3Oto-rhino-laryngologie Hôpital de Bicêtre AP-HP 78 rue du Général Leclerc 94275 Le Kremlin Bicêtre France Contributed equally Corresponding author Xavier Mariette Received 5 Dec 2005 Revisions requested 19 Jan 2006 Revisions received 1 Feb 2006 Accepted 6 Feb 2006 Published 3 Mar 2006 Arthritis Research Therapy 2006 8 R51 doi ar1 912 This article is online at http content 8 2 R51 2006 Ittah et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract B cell-activating factor BAFF has a key role in promoting B-lymphocyte activation and survival in primary Sjogren s syndrome pSS . The cellular origin of BAFF overexpression in salivary glands of patients with pSS is not fully known. We investigated whether salivary gland epithelial cells SGECs the main targets of autoimmunity in pSS could produce and express BAFF. We used quantitative RT-PCR ELISA and immunocytochemistry in cultured SGECs from eight patients with pSS and
