Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis. | Available online http content 8 3 R56 Research article Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis Sebastian Koelling Till Sebastian Clauditz Matthias Kaste and Nicolai Miosge Zentrum Anatomie Abt. Histologie Georg-August-Universitaet Kreuzbergring 36 37075 Gottingen Germany Corresponding author Nicolai Miosge nmiosge@ Received 3 Oct 2005 Revisions requested 14 Nov 2005 Revisions received 10 Feb 2006 Accepted 14 Feb 2006 Published 15 Mar 2006 Arthritis Research Therapy 2006 8 R56 doi ar1 922 This article is online at http content 8 3 R56 2006 Koelling et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract As a member of the thrombospondin gene family cartilage oligomeric protein COMP is found mainly in the extracellular matrix often associated with cartilage tissue. COMP exhibits a wide binding repertoire and has been shown to be involved in the regulation of chondrogenesis in vitro. Not much is known about the role of COMP in human cartilage tissue in vivo. With the help of immunohistochemistry Western blot in situ hybridization and real-time reverse transcription-polymerase chain reaction we aimed to elucidate the role of COMP in human embryonic adult healthy and osteoarthritis OA cartilage tissue. COMP is present during the earliest stages of human limb maturation and is later found in regions where the joints develop. In healthy and diseased cartilage tissue COMP is secreted by the chondrocytes and is often associated with the collagen fibers. In late stages of OA five times the COMP mRNA is produced by chondrocytes found in an area adjacent to the main defect than in
