Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Patients, their doctors, nonsteroidal anti-inflammatory drugs and the perception of risk. | Available online http content 8 2 105 Commentary Patients their doctors nonsteroidal anti-inflammatory drugs and the perception of risk Lawrence Goldkind1 and Lee S Simon2 1 Department of Gastroenterology Uniformed Services University of the Health Sciences Bethesda Maryland USA 2Department of Medicine Beth Israel Deaconess Medical Center Harvard Medical School Boston Massachusetts USA Corresponding author Lawrence Goldkind sgoldkind@ Published 2 March 2006 This article is online at http content 8 2 105 2006 BioMed Central Ltd Arthritis Research Therapy 2006 8 105 doi ar1924 Abstract This article is about risk. Risk is probably the most misunderstood component in determining therapeutic intervention however it is probably the most relevant issue to consider in the context of expected benefit. The rarity of quantitative risk-benefit assessment and the lack of comparative risk-benefit when alternative therapies exist for a given condition leads to inadequate decisions. Without some quantitation of the risks associated with specific therapies doctors and patients cannot make optimal risk-benefit calculations. Patients may abandon effective therapies for which benefits may still outweigh risks or opt for therapies with less well-publicized potential adverse events of even greater frequency or severity. When only small incremental benefits accrue to patients from the use of a given therapy on the other hand even very rare serious events may play a role in decision-making by patients by their health care providers and by regulatory authorities. Risk is inherent to essentially all drug therapy. Any pharmacological therapy is likely to have some risk of adverse effects in some patients. If an adverse event is mild and reversible it generally is not a significant issue in the choice of drug therapy for clinicians or patients. If the potential adverse event is considered severe and or serious however it becomes .
