Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: A promoter haplotype of the interleukin-18 gene is associated with juvenile idiopathic arthritis in the Japanese population. | Available online http content 8 3 R60 Research article A promoter haplotype of the interleukin-18 gene is associated with juvenile idiopathic arthritis in the Japanese population Tomoko Sugiura1 Nobuaki Maeno2 Yasushi Kawaguchi1 Syuji Takei3 Hiroyuki Imanaka4 Yoshifumi Kawano4 Hisae Terajima-Ichida1 Masako Hara1 and Naoyuki Kamatani1 institute of Rheumatology Tokyo Women s Medical University School of Medicine 10-22 Kawada-cho Shinjuku-ku Tokyo Japan 2Department of Infection and Immunity Kagoshima University Graduate School of Medical and Dental Sciences 8-35-1 Sakuragaoka Kagoshima Japan 3School of Health Sciences Faculty of Medicine Kagoshima University 8-35-1 Sakuragaoka Kagoshima Japan 4Department of Pediatrics Kagoshima University Graduate School of Medical and Dental Sciences 8-35-1 Sakuragaoka Kagoshima Japan Corresponding author Yasushi Kawaguchi y-kawa@ Received 4 Jan 2006 Revisions requested 1 Feb 2006 Revisions received 7 Feb 2006 Accepted 22 Feb 2006 Published 1 7 Mar 2006 Arthritis Research Therapy 2006 8 R60 doi ar1 930 This article is online at http content 8 3 R60 2006 Sugiura et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Recently we reported that genetic polymorphisms within the human IL18 gene were associated with disease susceptibility to adult-onset Still s disease AOSD which is characterized by extraordinarily high serum levels of IL-18. Because high serum IL-18 induction has also been observed in the systemic type of juvenile idiopathic arthritis JIA we investigated whether similar genetic skewing is present in this disease. Three haplotypes S01 S02 and S03 composed of 13 genetic polymorphisms covering two
