Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus. | Available online http content 8 3 R68 Research article The in vivo expression of actin salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus Anthony P Manderson1 2 Francesco Carlucci1 Peter J Lachmann3 Robert A Lazarus4 Richard J Festenstein5 H Terence Cook6 Mark J Walport1 7 and Marina Botto1 Rheumatology Section Division of Medicine Faculty of Medicine Imperial College London UK institute of Molecular Biosciences The University of Queensland Brisbane 4072 Australia 3Department of Veterinary Medicine University of Cambridge Cambridge UK 4Department of Protein Engineering Genentech Inc. CA USA 5Gene Control Mechanisms and Disease Imperial College London UK 6Department of Histopathology Faculty of Medicine Imperial College London UK 7The Wellcome Trust London UK Corresponding author Marina Botto Received 27 Jan 2006 Revisions requested 14 Feb 2006 Revisions received 10 Mar 2006 Accepted 14 Mar 2006 Published 10 Apr 2006 Arthritis Research Therapy 2006 8 R68 doi ar1 936 This article is online at http content 8 3 R68 2006 Manderson et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Systemic lupus erythematosus SLE is characterised by the production of autoantibodies against ubiquitous antigens especially nuclear components. Evidence makes it clear that the development of these autoantibodies is an antigen-driven process and that immune complexes involving DNA-containing antigens play a key role in the disease process. In rodents DNase I is the major endonuclease present in saliva urine and plasma where it catalyses the .
