Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis. | Available online http content 8 3 R69 Research article The S100A8 A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis Katsue Sunahori1 Masahiro Yamamura1 Jiro Yamana1 Kouji Takasugi1 Masanori Kawashima1 Hiroshi Yamamoto2 Walter J Chazin3 Yuichi Nakatani4 Satoru Yui4 and Hirofumi Makino1 Open Access Department of Medicine and Clinical Science Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University 2-5-1 Shikata-cho Okayama 700-8558 Japan 2Department of Biochemistry and Molecular Vascular Biology Graduate School of Medical Science Kanazawa University 13-1 Takara-machi Kanazawa 920-8640 Japan 3Department of Biochemistry and Physics Center for Structural Biology Vanderbilt University 465 21st Avenue Nashville TN 87232-8725 USA 4Faculty of Pharmaceutical Sciences Teikyo University 1 091-1 Sagamiko Tsukui-gun Kanagawa 199-0195 Japan Corresponding author Masahiro Yamamura yamamura@ Received 31 May 2005 Revisions requested 23 Jun 2006 Revisions received 12 Mar 2006 Accepted 15 Mar 2006 Published 13 Apr 2006 Arthritis Research Therapy 2006 8 R69 doi ar1 939 This article is online at http content 8 3 R69 2006 Yamamura et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract S100A8 and S100A9 two Ca2 -binding proteins of the S100 family are secreted as a heterodimeric complex S100A8 A9 from neutrophils and monocytes macrophages. Serum and synovial fluid levels of S100A8 S100A9 and S100A8 A9 were all higher in patients with rheumatoid arthritis RA than in patients with osteoarthritis OA with the S100A8
