Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Detection of somatostatin receptors in human osteosarcoma | BioMed Central World Journal of Surgical Oncology Research Detection of somatostatin receptors in human osteosarcoma Markos loannou 1 Panayiotis J Papagelopoulos2 loannis Papanastassiou1 Ioanna Iakovidou3 Stamatios Kottakis1 and Nikolaos Demertzis1 Address Department of Orthopaedic Surgery Cancer Hospital Pireus Greece 21st Department of Orthopaedic Surgery Medical School University of Athens Greece and 3Department of Pathology Cancer Hospital Pireus Greece Email Markos loannou - markosioannou@ Panayiotis J Papagelopoulos - pjp@ loannis Papanastassiou - jpapa73@ Ioanna lakovidou - yian_kyr@ Stamatios Kottakis - dmytas@ Nikolaos Demertzis - stavrosmitas@ Corresponding author Open Access Published 10 September 2008 Received 14 December 2007 World Journal of Surgical Oncology 2008 6 99 doi l477-78l 9-6-99 Accepted 10 September 2008 This article is available from http content 6 l 99 2008 Ioannou et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The location of osteosarcoma in the metaphysis as well as the age of the patients during the most rapid tumour growth suggest that factors related to skeletal growth are involved in the pathogenesis of this tumour. In this aspect this study aims to detect somatostatin receptors in human osteosarcomas and correlate this finding with the clinical outcome of the tumour. Patients and methods Immunohistochemical staining for the presence of somatostatin receptors as well as overall survival and disease free survival rates were retrospectively studied in twenty-nine osteosarcoma patients. Results Four osteosarcomas with several aggressive biologic behaviour expressed somatostatin receptors. In .
