Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. | Available online http content 8 3 R80 Research article The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocyteS David Magne1 Gaby Palmer1 Jenny L Barton3 Francoise Mezin1 Dominique Talabot-Ayer1 Sylvette Bas1 Trevor Duffy1 Marcus Noger3 Pierre-Andre Guerne1 Martin JH Nicklin2 and Cem Gabay1 1 Division of Rheumatology Department of Internal Medicine University Hospital and Department of Pathology and Immunology University of Geneva School of Medicine Geneva Switzerland 2Division of Genomic Medicine University of Sheffield Henry Wellcome Laboratories for Medical Research Medical School Sheffield UK 3Department of Orthopedic Surgery University Hospital of Geneva Geneva Switzerland Contributed equally Corresponding author Cem Gabay Received 28 Feb 2005 Revisions requested 14 Apr 2005 Revisions received 8 Mar 2006 Accepted 24 Mar 2006 Published 28 Apr 2006 Arthritis Research Therapy 2006 8 R80 doi ar1 946 This article is online at http content 8 3 R80 2006 Magne et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Six novel members of the IL-1 family of cytokines were recently identified primarily through the use of DNA database searches for IL-1 homologues and were named IL-1F5 to IL-1F10. In the present study we investigated the effect of IL-1F8 on primary human joint cells and examined the expression of the new IL-1 family members in human and mouse joints. Human synovial fibroblasts hSFs and human articular chondrocytes hACs expressed the IL-1F8 receptor IL-1Rrp2 and produced pro-inflammatory mediators in response to recombinant IL-1F8. IL-1F8 mRNA .
