Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Local treatment with the selective IκB kinase β inhibitor NEMO-binding domain peptide ameliorates synovial inflammation. | Available online http content 8 4 R86 Open Access Research article Local treatment with the selective IkB kinase p inhibitor NEMO-binding domain peptide ameliorates synovial inflammation Sander W Tas1 Margriet J Vervoordeldonk1 Najat Hajji1 Michael J May2 Sankar Ghosh3 and Paul P Tak1 Division of Clinical Immunology and Rheumatology F4-218 Academic Medical Center University of Amsterdam PO Box 22700 1100 DE Amsterdam The Netherlands 2School of Veterinary Medicine Department of Animal Biology University of Pennsylvania 3800 Spruce Street Philadelphia PA 19104-6046 USA 3Immunobiology Section Yale University Medical School 300 Cedar Street New Haven CT 06519 USA Corresponding author Paul PTak Received 22 Sep 2005 Revisions requested 2 Nov 2005 Revisions received 13 Mar 2006 Accepted 18 Apr 2006 Published 9 May 2006 Arthritis Research Therapy 2006 8 R86 doi ar1 958 This article is online at http content 8 4 R86 2006 Tas et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Nuclear factor NF -kB is a key regulator of synovial inflammation. We investigated the effect of local NF-kB inhibition in rat adjuvant arthritis AA using the specific IkB kinase IKK -p blocking NF-kB essential modulator-binding domain NBD peptide. The effects of the NBD peptide on human fibroblast-like synoviocytes FLS and macrophages as well as rheumatoid arthritis RA whole-tissue biopsies were also evaluated. First we investigated the effects of the NBD peptide on RA FLS in vitro. Subsequently NBD peptides were administered intra-articularly into the right ankle joint of rats at the onset of disease. The severity of arthritis was monitored over time rats were sacrificed on .
