Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: What determines the evolution of early undifferentiated arthritis and rheumatoid arthritis? An update from the Norfolk Arthritis Register. | Available online http content 8 4 214 Review Aspects of early arthritis What determines the evolution of early undifferentiated arthritis and rheumatoid arthritis An update from the Norfolk Arthritis Register Deborah PM Symmons and Alan J Silman arc Epidemiology Unit University of Manchester UK Corresponding author Deborah PM Symmons Published 14 June 2006 This article is online at http content 8 4 214 2006 BioMed Central Ltd Arthritis Research Therapy 2006 8 214 doi ar1979 Abstract Over 3500 patients with recent onset inflammatory polyarthritis IP have been recruited by the Norfolk Arthritis Register NOAR since 1990. Longitudinal data from this cohort have been used to examine the prevalence and predictors of remission functional disability radiological outcome cardiovascular mortality and co-morbidity and the development of non-Hodgkin s lymphoma. Rheumatoid factor titre high baseline C-reactive protein and high baseline HAQ score are all predictors of a poor outcome. There is a strong association between possession of the shared epitope and the development of erosions. Patients who satisfy the American College of Rheumatology criteria for rheumatoid arthritis RA have a worse prognosis than those who do not. However it appears that these patients are a poorly defined subset of all those with IP rather than having an entirely separate disease entity. New statistical techniques offer exciting possibilities for using longitudinal datasets such as NOAR to explore the long-term effects of treatment in IP and RA. Introduction The Norfolk Arthritis Register NOAR was established during 1989. By the beginning of 1990 all the general practitioners in what was then the Norwich Health Authority had been visited and asked to participate. From 1 January 1990 the general practitioners and local rheumatologists referred to NOAR all adults aged 16 whom they saw with two or more swollen joints .
