Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Independent associations of anti-cyclic citrullinated peptide antibodies and rheumatoid factor with radiographic severity of rheumatoid arthritis. | Available online http content 8 4 R1 28 Research article Independent associations of anti-cyclic citrullinated peptide antibodies and rheumatoid factor with radiographic severity of rheumatoid arthritis Devesh Mewar1 Annabel Coote1 David J Moore1 Ioanna Marinou1 Jodie Keyworth1 Marion C Dickson2 Doug S Montgomery2 Michael H Binks2 and Anthony G Wilson1 Division of Genomic Medicine University of Sheffield Sheffield UK 2GlaxoSmithKline R D Stevenage UK Corresponding author Anthony G Wilson Received 26 May 2006 Revisions requested 27 Jun 2006 Revisions received 7 Jul 2006 Accepted 20 Jul 2006 Published 20 Jul 2006 Arthritis Research Therapy 2006 8 R128 doi ar201 7 This article is online at http content 8 4 R1 28 2006 Mewar et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Several recent publications have established a strong association between anti-cyclic citrullinated peptide antibody anti-CCP -positive rheumatoid arthritis RA and carriage of shared epitope SE alleles. Although anti-CCP have also been associated with more severe RA the issue of whether this is independent of rheumatoid factor RF has not been addressed. To identify associations between RF anti-CCP SE status and radiological damage we studied a large cross-sectional cohort with longstanding RA. Individuals n 872 enrolled in the study all fulfilled the American College of Rheumatology criteria for RA had a minimum disease duration of 3 years and at least one definite radiographic erosion was present in hands or feet. Radiographs were scored blind at study entry by a single musculoskeletal radiologist using a modified Larsen s score. Anti-CCP and RF levels were
