Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis. | Available online http content 8 4 R130 Research article Statin-induced expression of CD59 on vascular endothelium in hypoxia a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis Anne R Kinderlerer1 Rivka Steinberg1 Michael Johns1 Sarah K Harten2 Elaine A Lidington1 Dorian O Haskard1 Patrick H Maxwell2 and Justin C Mason1 Open Access Cardiovascular Medicine Unit Eric Bywaters Center for Vascular Inflammation Imperial College London Hammersmith Hospital London UK 2The Renal Unit Imperial College London Hammersmith Hospital London UK Corresponding author Justin C Mason Received 30 Jan 2006 Revisions requested 21 Mar 2006 Revisions received 3 Jul 2006 Accepted 21 Jul 2006 Published 21 Jul 2006 Arthritis Research Therapy 2006 8 R130 doi ar2019 This article is online at http content 8 4 R130 2006 Kinderlerer et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Hypoxia which leads to dysfunctional cell metabolism and complement activation both play central roles in the pathogenesis of rheumatoid arthritis RA . Recent studies have reported that mice deficient for the complement-inhibitory protein CD59 show enhanced susceptibility to antigen-induced arthritis and reported that statins have anti-inflammatory effects in RA. We hypothesized that the anti-inflammatory effect of statins in RA relates in part to their ability to increase CD59 expression in hypoxic conditions and therefore to reduce complement activation. Flow-cytometric analysis showed that CD59 expression on endothelial cells EC was unaffected by atorvastatin in normoxia 21 O2 whereas in hypoxic conditions 1 O2 an up to threefold .
