Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Environmental risk factors differ between rheumatoid arthritis with and without auto-antibodies against cyclic citrullinated peptides. | Available online http content 8 4 R133 Research article Environmental risk factors differ between rheumatoid arthritis with and without auto-antibodies against cyclic citrullinated peptides Merete Pedersen1 Soren Jacobsen2 Mette Klarlund2 Bo V Pedersen1 Allan Wiik3 Jan Wohlfahrt1 and Morten Frisch1 Department of Epidemiology Research Danish Epidemiology Science Centre Statens Serum Institut Artillerivej 5 DK-2300 Copenhagen S Denmark department of Rheumatology University Hospital of Copenhagen Blegdamsvej 9 DK-2100 Copenhagen 0 Denmark 3Department of Autoimmunology Statens Serum Institut Artillerivej 5 DK-2300 Copenhagen S Denmark Corresponding author Merete Pedersen mtb@ Received 4 Mar 2006 Revisions requested 20 Apr 2006 Revisions received 11 Jul 2006 Accepted 27 Jul 2006 Published 27 Jul 2006 Arthritis Research Therapy 2006 8 R133 doi ar2022 This article is online at http content 8 4 R133 2006 Pedersen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The aim of this study was to evaluate new and previously hypothesised non-genetic risk factors for serologic subtypes of rheumatoid arthritis RA defined by the presence or absence of auto-antibodies to cyclic citrullinated peptides CCP . In a national case-control study we included 515 patients recently diagnosed with RA according to the American College of Rheumatology 1987 classification criteria and 769 gender- and age-matched population controls. Telephone interviews provided information about non-genetic exposures and serum samples for patients were tested for anti-CCP-antibodies. Associations between exposure variables and risk of anti-CCP-positive and anti-CCP-negative RA were .
