Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Familial, structural, and environmental correlates of MRI-defined bone marrow lesions: a sibpair study. | Available online http content 8 4 R137 Research article Familial structural and environmental correlates of MRI-defined bone marrow lesions a sibpair study Guangju Zhai1 2 James Stankovich3 Flavia Cicuttini4 Changhai Ding1 and Graeme Jones1 1Menzies Research Institute University of Tasmania Level 2 Surrey House 199 Macquarie Street Hobart TAS 7000 Australia 2Twin Research and Genetic Epidemiology Unit St Thomas s Hospital Lambeth Palace Road London SE1 7EH UK 3The Walter and Eliza Hall Institute of Medical Research 1G Royal Parade Parkville Melbourne VIC 3050 Australia 4Department of Epidemiology and Preventive Medicine Monash University Medical School 89 Commercial Road Alfred Hospital Melbourne VIC 3004 Australia Corresponding author Graeme Jones Received 11 May 2006 Revisions requested 7 Jun 2006 Revisions received 13 Jun 2006 Accepted 3 Aug 2006 Published 3 Aug 2006 Arthritis Research Therapy 2006 8 R137 doi ar2027 This article is online at http content 8 4 R137 2006 Zhai et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The aim of this study was to estimate the heritability and describe the correlates of bone marrow lesions in knee subchondral bone. A sibpair design was used. T2- and T1-weighted MRI scans were performed on the right knee to assess bone marrow lesions at lateral tibia and femora and medial tibia and femora as well as chondral defects. A radiograph was taken on the same knee and scored for individual features of osteoarthritis radiographic osteoarthritis ROA and alignment. Other variables measured included height weight knee pain and lower-limb muscle strength. Heritability was estimated with the program .
